Effect of Primidone on Liver-Related Biochemical Factors in Adult Male Rats

Background: Primidone is effective in the treatment of epilepsy. In this research, effect of primidone on liver- related biochemical factors in adult male rats was studied. Material and Methods: For this purpose, 40 adult male wistar rats, weighing approximately 180-200 g were divided into 5 groups of 8 animals. Groups: control group, Sham group and treatment at doses of 20 ,40 and 60 mg/kg, orally for 42 days (every other day) respectively. At the end of the experiment , liver weight were measured in all groups and then the blood sample was taken from heart and serum levels of albumin, total protein and total bilirubin were measured. The results were analyzed using ANOVA and tukey test statistical analysis. Results: the results show that liver weight in experimental groups had not a significant difference compared to control group. Serum level albumin and total protein in experimental groups had a significant decrease compared to control group. Serum level total bilirubin in experimental groups had a significant increase compared to control group (p≤0.05). Conclusion: Primidone decrease serum levels of albumin and total protein and increase serum level of total bilirubin.